CAR-T Toxicity Check: From Approval to Practice, Managing Side Effects of CAR-T Therapy

Jason Westin, MD, MS, FASCO MD Anderson Cancer Center | Surbhi Sidana, MD Stanford Medicine

May 16, 2025

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Key Points

  • Overview of CAR T cell therapy and its use in hematologic malignancies and solid tumors.

  • Mechanism of action: How CAR T cells are designed to attack cancer cells.

  • Acute side effects: Cytokine release syndrome (CRS) and neurotoxicity, including clinical pearls for treatment.

  • Chronic side effects: Infection monitoring, cytopenias, and risk of secondary malignancies.

  • The role of bridging therapy and tumor burden control prior to CAR T.

  • Guidance for community oncologists on patient care and communication with CAR T centers.