CAR-T Toxicity Check: From Approval to Practice, Managing Side Effects of CAR-T Therapy

Key Points

• Overview of CAR T cell therapy and its use in hematologic malignancies and solid tumors.

• Mechanism of action: How CAR T cells are designed to attack cancer cells.

• Acute side effects: Cytokine release syndrome (CRS) and neurotoxicity, including clinical pearls for treatment.

• Chronic side effects: Infection monitoring, cytopenias, and risk of secondary malignancies.

• The role of bridging therapy and tumor burden control prior to CAR T.

• Guidance for community oncologists on patient care and communication with CAR T centers.